Reference intervals for the dog — biochemistry, haematology, urinalysis and specialised tests, in one place, with the provenance of every value stated.
Hover any value to see its source and how to check it. The symbol tells you what kind of evidence it is.
- 🔗 156 — Online source — click and verify
156 of 156 values (100%) can be checked by anyone, today, without asking us.
Biochemistry
Serum and plasma biochemistry, blood gases and acid–base — 38 values, every one cited.
Haematology
Complete blood count, red cell indices, reticulocytes and platelet fractions — 32 values, every one cited.
Urinalysis
Urine concentration, protein and tubular injury markers — 14 values, every one cited.
Coagulation and viscoelastic testing
Clotting times, inhibitors, fibrinolysis and whole-blood viscoelastic testing — 7 values, every one cited.
Endocrine and reproductive assays
Adrenal, thyroid, pancreatic and gonadal hormones, including stimulation-test values — 21 values, every one cited.
| Marker | Reference interval | Source |
|---|---|---|
| 17-OH-progesterone | 6-20 ng/dL | LABOKLIN — Reference ranges |
| 25-hydroxyvitamin D | 112-366 nmol/L | Michigan State University VDL Endocrinology |
| ACTH endogenous | 6-58 pg/mL | LABOKLIN — Reference ranges |
| Androstenedione | spayed female baseline 0.05-0.57 spayed female post-ACTH 0.27-3.97 ng/mL (reference interval) | University of Tennessee Veterinary Medical Cen |
| Anti-Müllerian hormone | female ovariectomized 0.01-0.04 female inconclusive 0.05-0.10 female intact 0.11-3.91 male intact 11-535 ng/mL (interpretive bands) | UC Davis Clinical Endocrinology Laboratory |
| Calcitriol | 20-78 pmol/L | Michigan State University VDL Endocrinology |
| Cortisol basal | 5-65 ng/mL | LABOKLIN — Reference ranges |
| Estradiol | spayed female baseline 30.8-69.9 spayed female post-ACTH 27.9-69.2 pg/mL (reference interval) | University of Tennessee Veterinary Medical Cen |
| Free T3 | 3.7-9.2 pmol/L | LABOKLIN — Reference ranges |
| Free T4 | 7.7-47.6 pmol/L | LABOKLIN — Reference ranges |
| IGF i | 61-527 ng/mL | Michigan State University VDL Endocrinology |
| Insulin | 8-25 µU/mL | LABOKLIN — Reference ranges |
| Insulin autoantibodies | baseline <20 % (interpretive bands) | Michigan State University VDL Endocrinology |
| Insulin glucose ratio | dog fasting 0.11-0.33 dog ivgtt 15 min 0.08-0.36 dog ivgtt 30 min 0.11-0.34 dog ivgtt 45 min 0.11-0.26 dog ivgtt 60 min 0.13-0.25 ratio (reference interval) | Michigan State University VDL Endocrinology |
| Progesterone | anestrus <3 15 days post estrus 64-95 30 days post estrus 25-51 60 days post estrus 3-10 nmol/L (interpretive bands) | Michigan State University VDL Endocrinology |
| T3 | 20-206 ng/dL | LABOKLIN — Reference ranges |
| T3 autoantibody index | 0-10 % | Michigan State University VDL Endocrinology |
| T4 autoantibody index | 0-20 % | Michigan State University VDL Endocrinology |
| TSH | 0.03-0.50 ng/mL | UC Davis VMTH Clinical Chemistry Reference Int |
| Testosterone | intact male baseline 2.6-13.9 intact male 1 h post-hCG GnRH 13.0-17.3 intact male 2 h post-hCG GnRH 3.5-20.8 castrate female <0.7 nmol/L (interpretive bands) | Michigan State University VDL Endocrinology |
| Total T4 | 1.3-4.5 µg/dL | LABOKLIN — Reference ranges |
Trace elements, vitamins and amino acids
Micronutrient status, vitamin metabolites, plasma amino acids and toxic metals — 17 values, every one cited.
| Marker | Reference interval | Source |
|---|---|---|
| Arsenic | 0.417-8.17 µg/L | Larrán et al. |
| Chromium | 2.41-13.3 µg/L | Larrán et al. |
| Cobalamin | 300-800 ng/L | LABOKLIN — Reference ranges |
| Cobalt | 0.039-1.33 µg/L | Larrán et al. |
| Copper | 0.20-0.80 ppm | UPEI Veterinary Diagnostic Services |
| Folate | 3.0-10.0 ng/mL | LABOKLIN — Reference ranges |
| Homocysteine | 5.8-29.0 µmol/L | Canine cobalamin-related metabolite reference |
| Iron | 15-45 µmol/L | LABOKLIN — Reference ranges |
| Lead | 0.285-2.82 µg/L | Larrán et al. |
| Manganese | 1.90-7.28 µg/L | Larrán et al. |
| Mercury | 0.235-2.33 µg/L | Larrán et al. |
| Molybdenum | 1.43-12.7 µg/L | Larrán et al. |
| Nickel | 0.567-9.04 µg/L | Larrán et al. |
| Serum methylmalonic acid | 45.3-159.5 µg/L | Canine cobalamin-related metabolite reference |
| Taurine | current uc davis laboratory normal range 200-350 current uc davis risk interpretation >150 nmol/mL (interpretive bands) | UC Davis Amino Acid Laboratory — plasma and wh |
| Thiamine pyrophosphate | 70.9-135.3 µg/L | Peer-reviewed canine TPP reference interval st |
| Zinc | 0.70-2.00 ppm | UPEI Veterinary Diagnostic Services |
Other specialised assays
Pancreatic and inflammatory markers, cardiac and renal function tests, cerebrospinal fluid and therapeutic drug monitoring — 27 values, every one cited.
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Sources
All 39 sources behind the values on this page. The number after each value points here. Nothing here comes from anywhere else.
- 🔗 Andrews GA, Smith JE, Gray M, et al. An improved ferritin assay for canine sera. Vet Clin Pathol. 1992;21(2):57-60 — doi:10.1111/j.1939-165x.1992.tb00584.x · PMID 12671803
- 🔗 Animal Health Laboratory, University of Guelph — Biochemistry reference intervals (accessed 2026-08-09) — https://www.uoguelph.ca/ahl/biochemistry-reference-intervals
- 🔗 Berlin N, Pfaff A, Rozanski EA, et al. Establishment of a reference interval for thiamine concentrations in healthy dogs and evaluation of the prevalence of absolute thiamine deficiency in critically ill dogs with and without sepsis using high-performance liquid chromatography. J Vet Emerg Crit Care (San Antonio). 2024;34(1):49-56 — doi:10.1111/vec.13341 · PMID 37987121
- 🔗 Bexfield NH, Heiene R, Gerritsen RJ, et al. Glomerular filtration rate estimated by 3-sample plasma clearance of iohexol in 118 healthy dogs. J Vet Intern Med. 2008;22(1):66-73 — doi:10.1111/j.1939-1676.2007.0035.x · PMID 18289291
- 🔗 Brunker JD, Ponzio NM, Payton ME. Indices of urine N-acetyl-beta-D-glucosaminidase and gamma-glutamyl transpeptidase activities in clinically normal adult dogs. Am J Vet Res. 2009;70(2):297-301 — doi:10.2460/ajvr.70.2.297 · PMID 19231965
- 🔗 Cornell AHDC / eClinPath (Cobas c501 chem, Advia 2120 heme; >=120 healthy adults) — https://eclinpath.com/test-basics/reference-intervals/
- 🔗 Cornell AHDC / eClinPath — Coagulation reference intervals — https://eclinpath.com/test-basics/reference-intervals/
- 🔗 Cornell AHDC Immunology — testing protocols and interpretation guidelines — https://www.vet.cornell.edu/animal-health-diagnostic-center/testing/testing-protocols-interpretations/immunology/ana-anti-nuclear-antibody
- 🔗 Cornell AHDC — Clinical Pathology, Chemistry (Cobas c501) reference intervals, serum only — https://www.vet.cornell.edu/animal-health-diagnostic-center/laboratories/clinical-pathology/reference-intervals/chemistry-cobas
- 🔗 Cornell AHDC — Haematology reference intervals, Advia 2120 (absolute and percentage differential tables) — https://www.vet.cornell.edu/animal-health-diagnostic-center/laboratories/clinical-pathology/reference-intervals/hematology-advia-2120
- 🔗 Davis J, Raisis AL, Miller DW, et al. Analytical validation and reference intervals for a commercial multiplex assay to measure five novel biomarkers for acute kidney injury in canine urine. Res Vet Sci. 2021;139:78-86 — doi:10.1016/j.rvsc.2021.07.009 · PMID 34261014
- 🔗 eClinPath (Cornell AHDC) — Acid-base: specific disturbances (mleczan L- i D-) — https://eclinpath.com/chemistry/acid-base/types-of-disturbances/specific-disturbances/
- 🔗 eClinPath (Cornell AHDC) — Nucleated RBC test page — https://eclinpath.com/hematology/tests/nucleated-rbc/
- 🔗 Fuchs J, Moritz A, Grußendorf E, et al. Evaluation of reticulocyte hemoglobin content (RET-He) in the diagnosis of iron-deficient erythropoiesis in dogs. Vet Clin Pathol. 2017;46(4):558-568 — doi:10.1111/vcp.12547 · PMID 28991391
- 🔗 Gori E, Pierini A, Pasquini A, et al. The erythrocyte sedimentation rate (ESR) in canine inflammation. Vet J. 2023;294:105949 — doi:10.1016/j.tvjl.2022.105949 · PMID 36581149
- 🔗 IDEXX Laboratories — Interpretive Criteria for the Canine Cardiopet proBNP Test (2013); TEST cut-offs, not a species reference interval — https://www.idexx.com/files/cardiopet-interpretive-criteria-canine.pdf
- 🔗 IDEXX Reference Laboratories — SDMA reference interval — https://www.idexx.com/en/veterinary/reference-laboratories/sdma/
- 🔗 Iowa State University Veterinary Diagnostic Laboratory — Clinical Pathology Reference Intervals (February 2011) — https://vetmed.iastate.edu/vpath/services/diagnostic-services/clinical-pathology-diagnostic-and-research-services/testing-and-fees/reference-intervals/
- 🔗 IRIS (International Renal Interest Society) guidelines — USG/UPC — https://www.iris-kidney.com/iris-guidelines-1
- 🔗 LABOKLIN — Reference ranges, small animals (document 07/2024) — https://laboklin.com/en/specialist-information/reference-values/
- 🔗 Larrán B, López-Alonso M, Miranda M, et al. Reference Intervals for Trace Elements in Canine Plasma. Animals (Basel). 2026;16(2) — doi:10.3390/ani16020264
- 🔗 Merck Veterinary Manual — Hematologic Reference Ranges — https://www.merckvetmanual.com/special-subjects/reference-guides/hematologic-reference-ranges
- 🔗 Merck Veterinary Manual — Serum Biochemical Reference Ranges — https://www.merckvetmanual.com/multimedia/table/serum-biochemical-analysis-reference-ranges
- 🔗 Michigan State University VDL Endocrinology (2025-06-26) — https://cvm.msu.edu/assets/documents/VDL/Endocrinology-Reference-Ranges.pdf
- 🔗 Navarro PF et al., Animals 2025;15(23):3376 — reference intervals for haematological inflammatory ratios in 156 healthy dogs (nonparametric, Reference Value Advisor 2.0) — https://doi.org/10.3390/ani15233376
- 🔗 Perez-Ecija A, Martinez C, Fernandez-Castañer J, et al. The Immature Reticulocyte Fraction (IRF) in the Sysmex XN-1000V Analyzer Can Differentiate between Causes of Regenerative and Non-Regenerative Anemia in Dogs and Cats. Animals (Basel). 2024;14(2) — doi:10.3390/ani14020349
- 🔗 Perez-Ecija A, Martinez C, Fernandez-Castañer J, et al. Utility of immature platelet fraction in the Sysmex XN-1000V for the differential diagnosis of central and peripheral thrombocytopenia in dogs and cats. J Vet Intern Med. 2024;38(3):1512-1519 — doi:10.1111/jvim.17074 · PMID 38619127
- 🔗 Proksch AL, Schaefer S, Dreller V, et al. The effects of age and sex on reference intervals for cobalamin, homocysteine, and serum and urinary methylmalonic acid in healthy adult dogs. J Vet Intern Med. 2025;39(1):e17250 — doi:10.1111/jvim.17250
- 🔗 Reusch C, Vochezer R, Weschta E. Enzyme activities of urinary alanine aminopeptidase (AAP) and N-acetyl-beta-D-glucosaminidase (NAG) in healthy dogs. Zentralbl Veterinarmed A. 1991;38(2):90-8 — doi:10.1111/j.1439-0442.1991.tb00988.x · PMID 1677227
- 🔗 Sekisui Diagnostics SDH Assay (2023) — https://sekisuidiagnostics.com/wp-content/uploads/2023/01/IN74025-2.pdf
- 🔗 Texas A&M Gastrointestinal Laboratory — Spec cPL / Spec fPL reference ranges and pancreatitis cut-offs — https://vetmed.tamu.edu/gilab/service/assays/pli/
- 🔗 UC Davis Amino Acid Laboratory — plasma and whole-blood taurine reference ranges (sample submission form) — https://www.vetmed.ucdavis.edu/labs/amino-acid-laboratory
- 🔗 UC Davis Clinical Endocrinology Laboratory (2025-07) — https://www.vetmed.ucdavis.edu/sites/g/files/dgvnsk491/files/inline-files/2025-Sample-Handling-Instructions-Reference-Ranges.pdf
- 🔗 UC Davis VMTH Clinical Chemistry Reference Intervals, Rev 6/2025 (multi-species table; column-verified) — https://www.vetmed.ucdavis.edu/sites/g/files/dgvnsk491/files/inline-files/Chemistry_Reference_Intervals_6.2025_0.pdf
- 🔗 University of Tennessee Veterinary Medical Center Endocrinology (2020) — https://vetmed.tennessee.edu/wp-content/uploads/sites/4/Newsletter-Adrenal-panel-2020.pdf
- 🔗 UPEI Veterinary Diagnostic Services (Atlantic Veterinary College) — Reference intervals for trace elements in serum — https://diagnosticservices.avc.upei.ca/reference-guide/reference-intervals/
- 🔗 Veterian Key — Metabolic Acid-Base Disorders — https://veteriankey.com/metabolic-acid-base-disorders/
- 🔗 Veterian Key — Metabolic Encephalopathy: Osmolality — https://veteriankey.com/metabolic-encephalopathy-osmolality/
- 🔗 Vetspace (Ron Hines) — Normal Dog and Cat Blood Chemistry and Lab Values — https://vetspace.2ndchance.info/normal-dog-and-cat-blood-chemistry-and-lab-values/
Method
Evidence-based veterinary medicine (EBVM) only. This page follows the principles of evidence-based veterinary medicine: every value is traceable to a named source, and where the evidence does not exist we say so. A value appears here solely when it can be traced to a named source: a laboratory reference document, an established veterinary clinical pathology reference, or peer-reviewed literature. There is no category of “commonly quoted” or “textbook approximate” value on this site.
Gaps stay gaps. Where an interval has not been established, the entry is absent. We do not substitute a value from a related species and we do not average across sources. 0 values held internally are withheld from these pages because their provenance is not recorded.
One dataset. Every number here is the number our articles use, with the same source attached.
Derived values are labelled. Where an interval was calculated from a published mean and standard deviation rather than formally established, the source entry says so explicitly.
Marcin Siedlecki. Dog Blood Test Reference Ranges. VetBlood, 2026. https://vetblood.io/veterinary-reference-ranges/dog/
Quote or reference it, in whole or in part, with attribution and a link back.
Compiled by Marcin Siedlecki. Last reviewed 2026-08-12. Corrections are welcome at vetblood@vetblood.io — if a value here disagrees with a source you trust, tell us and we will check it.